Development of Folate‐Superparamagnetic Nanoconjugates for Inhibition of Cancer Cell Proliferation

Abstract Here, a versatile strategy to engineer smart theranostic nanocarriers is reported. The core/shell nanosystem composed of superparamagnetic iron oxide (Fe 3− δ O 4 ) nanoparticle (NP) core bearing the biocompatible thermo‐responsive poly(2‐(2‐methoxy)ethyl methacrylate‐oligo(ethylene glycol methacrylate), P(MEO 2 MA x ‐OEGMA 100− copolymer (where and 100‐ represent molar fractions MEO OEGMA, respectively). Folic acid (FA) end‐conjugated copolymer, leading Fe 3 − @P(MEO )‐FA, facilitate active targeting NPs cancer cells. A highly potent hydrophobic anticancer agent doxorubicin (DOX) incorporated in y brushes via supramolecular interactions increase its solubility assessment therapeutic potentials. These experiments confirm magnetic hyperthermia properties nanocarrier reveal that only small amount (10% ± 4%) DOX diffused at room temperature, while almost full drug (100%) released after 52 h 41 °C. Interestingly, it found 60 40 polymers offer promising stealth behavior against Human Serum Albumin Fibrinogen model proteins.